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Assay Detail

CHEMBL649775

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]-CGS- 21680 from adenosine A2a receptor of bovine striatal membrane
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Adenosine receptor A2a (CHEMBL251)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

3-Aryl[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-ones: a new class of selective A1 adenosine receptor antagonists.
Da Settimo F, Primofiore G, Taliani S, Marini AM, La Motta C, Novellino E, Greco G, Lavecchia A, Trincavelli L, Martini C.
J Med Chem (2001) 44 : 316 -327
PubMed 11462973 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 12 6.04 7.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL464859 NECA 1 7.80
CHEMBL7608 1 6.62
CHEMBL183 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] 1 6.47
CHEMBL307199 1 6.40
CHEMBL269112 1 5.99
CHEMBL109691 1 5.92
CHEMBL113518 1 5.91
CHEMBL7327 1 5.89
CHEMBL7113 1 5.54
CHEMBL7334 1 5.46
CHEMBL7953 1 5.30
CHEMBL7098 1 5.20

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL464859 NECA Ki = 16.0 nM 7.80
CHEMBL7608 Ki = 241.0 nM 6.62
CHEMBL183 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] Ki = 337.0 nM 6.47
CHEMBL307199 Ki = 401.0 nM 6.40
CHEMBL269112 Ki = 1023.0 nM 5.99
CHEMBL109691 Ki = 1200.0 nM 5.92
CHEMBL113518 Ki = 1236.0 nM 5.91
CHEMBL7327 Ki = 1300.0 nM 5.89
CHEMBL7113 Ki = 2900.0 nM 5.54
CHEMBL7334 Ki = 3500.0 nM 5.46
CHEMBL7953 Ki = 5000.0 nM 5.30
CHEMBL7098 Ki = 6300.0 nM 5.20