Assay Detail
Binding
CHEMBL649785
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Displacement of [3H]-ZM 241385 from Human Adenosine A2a receptor expressed in HEK293 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis, biological properties, and molecular modeling investigation of the first potent, selective, and water-soluble human A(3) adenosine receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.72 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL332091 | — | — | 1 | 7.22 |
| CHEMBL118923 | — | — | 1 | 7.00 |
| CHEMBL324735 | — | — | 1 | 6.42 |
| CHEMBL324512 | — | — | 1 | 6.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL332091 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL118923 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL324735 | — | Ki | = | 381.0 | nM | 6.42 |
| CHEMBL324512 | — | Ki | = | 594.0 | nM | 6.23 |