Assay Detail
Binding
CHEMBL649786
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Inhibition of [3H]CGS-21680 binding to human Adenosine A2a receptor expressed in HEK293 cells at 10000 nM
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
1,2,4-Triazolo[5,1-i]purine derivatives as highly potent and selective human adenosine A(3) receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.38 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL123705 | — | — | 1 | 7.51 |
| CHEMBL333860 | — | — | 1 | 7.31 |
| CHEMBL123462 | — | — | 1 | 7.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL123705 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL333860 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL123462 | — | Ki | = | 49.0 | nM | 7.31 |