Assay Detail
Binding
CHEMBL649868
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity for the adenosine A2 receptor was evaluated in a competition assay in rat striatum using [3H]-CGS- 21680 as radioligand
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
2-Alkynyl derivatives of adenosine-5'-N-ethyluronamide: selective A2 adenosine receptor agonists with potent inhibitory activity on platelet aggregation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 8.01 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2113405 | — | — | 1 | 9.30 |
| CHEMBL2113404 | — | — | 1 | 9.22 |
| CHEMBL2094083 | — | — | 1 | 9.05 |
| CHEMBL2113412 | — | — | 1 | 9.00 |
| CHEMBL2113399 | — | — | 1 | 8.77 |
| CHEMBL410873 | — | — | 1 | 8.66 |
| CHEMBL2113482 | — | — | 1 | 8.64 |
| CHEMBL2113402 | — | — | 1 | 8.33 |
| CHEMBL2113419 | — | — | 1 | 8.30 |
| CHEMBL2113407 | — | — | 1 | 8.17 |
| CHEMBL2113410 | — | — | 1 | 8.12 |
| CHEMBL464859 | NECA | — | 1 | 8.11 |
| CHEMBL2113411 | — | — | 1 | 8.04 |
| CHEMBL2113483 | — | — | 1 | 8.04 |
| CHEMBL2113414 | — | — | 1 | 7.97 |
| CHEMBL2113413 | — | — | 1 | 7.95 |
| CHEMBL2113417 | — | — | 1 | 7.56 |
| CHEMBL2113403 | — | — | 1 | 7.42 |
| CHEMBL2113486 | — | — | 1 | 7.41 |
| CHEMBL2113408 | — | — | 1 | 7.25 |
| CHEMBL2113449 | — | — | 1 | 7.24 |
| CHEMBL2113416 | — | — | 1 | 7.21 |
| CHEMBL2113485 | — | — | 1 | 6.36 |
| CHEMBL284969 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2113405 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL2113404 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL2094083 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL2113412 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL2113399 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL410873 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL2113482 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL2113402 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL2113419 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL2113407 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL2113410 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL464859 | NECA | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL2113411 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL2113483 | — | Ki | = | 9.1 | nM | 8.04 |
| CHEMBL2113414 | — | Ki | = | 10.8 | nM | 7.97 |
| CHEMBL2113413 | — | Ki | = | 11.3 | nM | 7.95 |
| CHEMBL2113417 | — | Ki | = | 27.3 | nM | 7.56 |
| CHEMBL2113403 | — | Ki | = | 38.3 | nM | 7.42 |
| CHEMBL2113486 | — | Ki | = | 39.4 | nM | 7.41 |
| CHEMBL2113408 | — | Ki | = | 56.4 | nM | 7.25 |
| CHEMBL2113449 | — | Ki | = | 57.8 | nM | 7.24 |
| CHEMBL2113416 | — | Ki | = | 61.3 | nM | 7.21 |
| CHEMBL2113485 | — | Ki | = | 441.0 | nM | 6.36 |
| CHEMBL284969 | — | Ki | = | 650.0 | nM | 6.19 |