Assay Detail
Binding
CHEMBL649870
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Affinity for adenosine A2 receptor at rat striatal membrane using 5 nM [3H]CGS-21680
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of N6-(p-sulfophenyl)alkyl and N6-sulfoalkyl derivatives of adenosine: water-soluble and peripherally selective adenosine agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.27 | 6.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL262083 | N6-PHENYLADENOSINE | — | 1 | 6.18 |
| CHEMBL2113406 | — | — | 1 | 5.32 |
| CHEMBL2113577 | — | — | 1 | 5.06 |
| CHEMBL2364548 | — | — | 1 | 5.05 |
| CHEMBL604406 | — | — | 1 | 5.05 |
| CHEMBL2113574 | — | — | 1 | 4.95 |
| CHEMBL610435 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL262083 | N6-PHENYLADENOSINE | Ki | = | 663.0 | nM | 6.18 |
| CHEMBL2113406 | — | Ki | = | 4750.0 | nM | 5.32 |
| CHEMBL2113577 | — | Ki | = | 8780.0 | nM | 5.06 |
| CHEMBL2364548 | — | Ki | = | 8900.0 | nM | 5.05 |
| CHEMBL604406 | — | Ki | = | 8900.0 | nM | 5.05 |
| CHEMBL2113574 | — | Ki | = | 11300.0 | nM | 4.95 |
| CHEMBL610435 | — | Ki | = | - | nM | - |