Assay Detail
Binding
CHEMBL649872
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Affinity for Adenosine A2 receptor determined by [3H]NECA binding to rat striatal membranes
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
High selectivity of novel isoguanosine analogues for the adenosine A1 receptor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 5.52 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL477 | ADENOSINE | 4.0 | 1 | 7.43 |
| CHEMBL1688963 | ISOGUANOSINE | — | 1 | 6.48 |
| CHEMBL45891 | — | — | 1 | 6.44 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 6.33 |
| CHEMBL607606 | — | — | 1 | 5.22 |
| CHEMBL608168 | — | — | 1 | 5.12 |
| CHEMBL608445 | — | — | 1 | 4.82 |
| CHEMBL608747 | — | — | 1 | 4.82 |
| CHEMBL607881 | — | — | 1 | 4.40 |
| CHEMBL608742 | — | — | 1 | 4.10 |
| CHEMBL608748 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL477 | ADENOSINE | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL1688963 | ISOGUANOSINE | Ki | = | 331.0 | nM | 6.48 |
| CHEMBL45891 | — | Ki | = | 363.0 | nM | 6.44 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | Ki | = | 462.0 | nM | 6.33 |
| CHEMBL607606 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL608168 | — | Ki | = | 7500.0 | nM | 5.12 |
| CHEMBL608445 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL608747 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL607881 | — | Ki | = | 40000.0 | nM | 4.40 |
| CHEMBL608742 | — | Ki | = | 80000.0 | nM | 4.10 |
| CHEMBL608748 | — | Ki | = | 140000.0 | nM | - |