Assay Detail
Binding
CHEMBL649877
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against Adenosine A2 receptor in rat striatum by displacement of [3H]N-ethyladenosine-5''-uronamide(NECA)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
1,3,8-trisubstituted xanthines. Effects of substitution pattern upon adenosine receptor A1/A2 affinity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.35 | 7.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL286347 | — | — | 1 | 7.15 |
| CHEMBL33722 | — | — | 1 | 6.76 |
| CHEMBL33169 | — | — | 1 | 6.50 |
| CHEMBL287010 | — | — | 1 | 6.46 |
| CHEMBL33893 | — | — | 1 | 6.14 |
| CHEMBL284598 | — | — | 1 | 5.92 |
| CHEMBL285212 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL286347 | — | Ki | = | 70.3 | nM | 7.15 |
| CHEMBL33722 | — | Ki | = | 173.0 | nM | 6.76 |
| CHEMBL33169 | — | Ki | = | 315.0 | nM | 6.50 |
| CHEMBL287010 | — | Ki | = | 347.0 | nM | 6.46 |
| CHEMBL33893 | — | Ki | = | 719.0 | nM | 6.14 |
| CHEMBL284598 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL285212 | — | Ki | = | 3100.0 | nM | 5.51 |