Assay Detail
Binding
CHEMBL649879
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Binding affinity against Adenosine A2 receptor using N-[3H]-ethyladenosin-5''-uronamide in rat striatal membranes
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
8-Polycycloalkyl-1,3-dipropylxanthines as potent and selective antagonists for A1-adenosine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.69 | 6.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL172950 | — | — | 1 | 6.25 |
| CHEMBL321507 | — | — | 1 | 6.07 |
| CHEMBL157655 | — | — | 1 | 5.62 |
| CHEMBL1355736 | THEOPHYLLINE | 4.0 | 1 | 4.80 |
| CHEMBL173327 | — | — | 1 | - |
| CHEMBL173102 | — | — | 1 | - |
| CHEMBL320147 | — | — | 1 | - |
| CHEMBL368276 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL172950 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL321507 | — | Ki | = | 850.0 | nM | 6.07 |
| CHEMBL157655 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL1355736 | THEOPHYLLINE | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL173327 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL173102 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL320147 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL368276 | — | Ki | > | 100000.0 | nM | - |