Assay Detail
Binding
CHEMBL649929
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic activity against labelled Bombesin receptor bb1 binding sites in rat olfactory bulb by using [125I]- [Tyr] bombesin in presence of [D-Phe-6] bombesin(6-13)ethyl ester; 0.31-1.3
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Olfactory bulb |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
PD 176252--the first high affinity non-peptide gastrin-releasing peptide (BB2) receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 9.18 | 9.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL405908 | — | — | 1 | 9.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL405908 | — | IC50 | = | 0.66 | nM | 9.18 |