Assay Detail
Binding
CHEMBL649937
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Inhibitory effect on Chemokine binding to C-C chemokine receptor type 5 using [125I]RANTES
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Discovery of novel, potent, and selective small-molecule CCR5 antagonists as anti-HIV-1 agents: synthesis and biological evaluation of anilide derivatives with a quaternary ammonium moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.38 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41275 | — | — | 1 | 8.85 |
| CHEMBL292548 | — | — | 1 | 8.85 |
| CHEMBL56565 | — | — | 1 | 8.82 |
| CHEMBL293393 | — | — | 1 | 8.74 |
| CHEMBL64322 | — | — | 1 | 8.74 |
| CHEMBL62339 | — | — | 1 | 8.66 |
| CHEMBL61208 | — | — | 1 | 8.51 |
| CHEMBL294788 | — | — | 1 | 8.48 |
| CHEMBL62180 | — | — | 1 | 8.42 |
| CHEMBL62598 | — | — | 1 | 8.35 |
| CHEMBL294501 | — | — | 1 | 8.17 |
| CHEMBL62549 | — | — | 1 | 7.60 |
| CHEMBL61267 | — | — | 1 | 7.37 |
| CHEMBL64163 | — | — | 1 | 6.96 |
| CHEMBL303964 | — | — | 1 | 6.62 |
| CHEMBL293882 | — | — | 1 | 6.42 |
| CHEMBL66301 | — | — | 1 | 6.41 |
| CHEMBL65681 | — | — | 1 | 6.37 |
| CHEMBL65696 | — | — | 1 | 6.24 |
| CHEMBL62454 | — | — | 1 | 6.21 |
| CHEMBL64591 | — | — | 1 | 6.18 |
| CHEMBL292345 | — | — | 1 | 6.08 |
| CHEMBL62611 | — | — | 1 | 5.96 |
| CHEMBL65649 | — | — | 1 | 5.92 |
| CHEMBL65605 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41275 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL292548 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL56565 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL293393 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL64322 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL62339 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL61208 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL294788 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL62180 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL62598 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL294501 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL62549 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL61267 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL64163 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL303964 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL293882 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL66301 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL65681 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL65696 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL62454 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL64591 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL292345 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL62611 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL65649 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL65605 | — | IC50 | = | 3200.0 | nM | 5.50 |