Assay Detail
Binding
CHEMBL649944
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of RANTES binding to C-C chemokine receptor type 5
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Discovery of 4-[(Z)-(4-bromophenyl)- (ethoxyimino)methyl]-1'-[(2,4-dimethyl-3- pyridinyl)carbonyl]-4'-methyl-1,4'- bipiperidine N-oxide (SCH 351125): an orally bioavailable human CCR5 antagonist for the treatment of HIV infection.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 8.14 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109051 | — | — | 1 | 9.00 |
| CHEMBL323172 | — | — | 1 | 8.96 |
| CHEMBL105821 | — | — | 1 | 8.96 |
| CHEMBL324643 | — | — | 1 | 8.74 |
| CHEMBL112686 | — | — | 1 | 8.70 |
| CHEMBL78535 | ANCRIVIROC | 2.0 | 1 | 8.68 |
| CHEMBL105784 | — | — | 1 | 8.47 |
| CHEMBL109158 | — | — | 1 | 8.35 |
| CHEMBL292625 | — | — | 1 | 8.15 |
| CHEMBL2111747 | — | — | 1 | 7.96 |
| CHEMBL106098 | — | — | 1 | 7.75 |
| CHEMBL106767 | — | — | 1 | 7.75 |
| CHEMBL112760 | — | — | 1 | 7.60 |
| CHEMBL108569 | — | — | 1 | 7.54 |
| CHEMBL331140 | — | — | 1 | 7.32 |
| CHEMBL106209 | — | — | 1 | 7.27 |
| CHEMBL106247 | — | — | 1 | 7.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109051 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL323172 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL105821 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL324643 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL112686 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL78535 | ANCRIVIROC | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL105784 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL109158 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL292625 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL2111747 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL106098 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL106767 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL112760 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL108569 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL331140 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL106209 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL106247 | — | Ki | = | 66.0 | nM | 7.18 |