Assay Detail
Binding
CHEMBL649945
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Inhibition of RANTES binding to the human C-C chemokine receptor type 5 (CCR5)
103
Total Activities
101
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Generation of predictive pharmacophore models for CCR5 antagonists: study with piperidine- and piperazine-based compounds as a new class of HIV-1 entry inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 103 | 7.95 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140484 | — | — | 1 | 10.00 |
| CHEMBL335365 | — | — | 1 | 9.52 |
| CHEMBL335794 | — | — | 1 | 9.40 |
| CHEMBL140827 | — | — | 1 | 9.15 |
| CHEMBL337776 | — | — | 1 | 9.15 |
| CHEMBL115487 | — | — | 1 | 9.00 |
| CHEMBL139559 | — | — | 1 | 8.96 |
| CHEMBL138285 | — | — | 1 | 8.96 |
| CHEMBL138640 | — | — | 1 | 8.92 |
| CHEMBL140418 | — | — | 1 | 8.89 |
| CHEMBL112760 | — | — | 2 | 8.70 |
| CHEMBL331140 | — | — | 2 | 8.70 |
| CHEMBL140390 | — | — | 1 | 8.70 |
| CHEMBL335120 | — | — | 1 | 8.68 |
| CHEMBL78535 | ANCRIVIROC | 2.0 | 1 | 8.68 |
| CHEMBL142021 | — | — | 1 | 8.66 |
| CHEMBL113436 | — | — | 1 | 8.64 |
| CHEMBL137934 | — | — | 1 | 8.64 |
| CHEMBL334470 | — | — | 1 | 8.57 |
| CHEMBL311795 | — | — | 1 | 8.52 |
| CHEMBL113072 | — | — | 1 | 8.52 |
| CHEMBL423000 | — | — | 1 | 8.52 |
| CHEMBL140552 | — | — | 1 | 8.49 |
| CHEMBL140912 | — | — | 1 | 8.48 |
| CHEMBL337340 | — | — | 1 | 8.47 |
| CHEMBL261950 | — | — | 1 | 8.42 |
| CHEMBL138975 | — | — | 1 | 8.40 |
| CHEMBL138274 | — | — | 1 | 8.36 |
| CHEMBL139029 | — | — | 1 | 8.35 |
| CHEMBL141202 | — | — | 1 | 8.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140484 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL335365 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL335794 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL140827 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL337776 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL115487 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL138285 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL139559 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL138640 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL140418 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL112760 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL331140 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL140390 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL335120 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL78535 | ANCRIVIROC | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL142021 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL113436 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL137934 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL334470 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL423000 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL113072 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL311795 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL140552 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL140912 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL337340 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL261950 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL138975 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL138274 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL139029 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL141202 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL113042 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL325276 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL111998 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL115716 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL343520 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL138502 | — | Ki | = | 5.23 | nM | 8.28 |
| CHEMBL141301 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL343826 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL141683 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL322251 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL292625 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL336246 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL326020 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL341945 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL325556 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL107154 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL341758 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL137856 | — | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL337364 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL337820 | — | Ki | = | 10.0 | nM | 8.00 |