Assay Detail
Functional
CHEMBL649980
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Concentration required to inhibit growth against CCRF-CEM cell
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and X-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 7.88 | 7.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL439973 | — | — | 1 | 7.90 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL439973 | — | EC50 | = | 12.5 | nM | 7.90 |
| CHEMBL34259 | METHOTREXATE | EC50 | = | 13.8 | nM | 7.86 |