Assay Detail
Binding
CHEMBL650034
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Compound was tested for inhibitory activity against beta-glucocerebrosidase.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis of potent -D-glucocerebrosidase inhibitors: N-alkyl--valienamines
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.51 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL422734 | — | — | 1 | 7.52 |
| CHEMBL176679 | — | — | 1 | 7.16 |
| CHEMBL170431 | — | — | 1 | 6.92 |
| CHEMBL369361 | — | — | 1 | 6.52 |
| CHEMBL426933 | — | — | 1 | 6.52 |
| CHEMBL354193 | — | — | 1 | 6.52 |
| CHEMBL174067 | — | — | 1 | 5.96 |
| CHEMBL367666 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL422734 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL176679 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL170431 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL369361 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL426933 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL354193 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL174067 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL367666 | — | IC50 | = | 11000.0 | nM | 4.96 |