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Assay Detail

CHEMBL650045

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity towards Beta-Glucosidase from Almond
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Prunus dulcis
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Beta-glucosidase (CHEMBL4192)
Type SINGLE PROTEIN
Organism Prunus avium

Publication

Derivatives of (2R,3R,4S)-2-aminomethylpyrrolidine-3,4-diol are selective alpha-mannosidase inhibitors.
Popowycz F, Gerber-Lemaire S, Demange R, Rodriguez-García E, Asenjo AT, Robina I, Vogel P.
Bioorg Med Chem Lett (2001) 11 : 2489 -2493
PubMed 11549453 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 4.16 4.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL83278 1 4.16
CHEMBL2207396 1 -
CHEMBL2206826 1 -
CHEMBL82895 1 -
CHEMBL84104 1 -
CHEMBL421340 1 -
CHEMBL84940 1 -
CHEMBL313295 1 -
CHEMBL2115197 1 -
CHEMBL445624 1 -
CHEMBL2207397 1 -
CHEMBL2206827 1 -
CHEMBL84272 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL83278 IC50 = 70000.0 nM 4.16
CHEMBL2207396 IC50 = 600000.0 nM -
CHEMBL2206826 IC50 = 410000.0 nM -
CHEMBL82895 IC50 = 420000.0 nM -
CHEMBL84104 IC50 = 370000.0 nM -
CHEMBL421340 IC50 = 550000.0 nM -
CHEMBL84940 IC50 = 500000.0 nM -
CHEMBL313295 IC50 = 140000.0 nM -
CHEMBL2115197 IC50 = 120000.0 nM -
CHEMBL445624 IC50 = 430000.0 nM -
CHEMBL2207397 IC50 = 120000.0 nM -
CHEMBL2206827 IC50 = 290000.0 nM -
CHEMBL84272 IC50 = 430000.0 nM -