Assay Detail
Binding
CHEMBL650119
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Inhibition of [125I]RANTES binding to CCR5 receptor.
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Oximino-piperidino-piperidine-based CCR5 antagonists. Part 2: synthesis, SAR and biological evaluation of symmetrical heteroaryl carboxamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 8.29 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL349008 | — | — | 1 | 9.52 |
| CHEMBL350563 | — | — | 1 | 9.40 |
| CHEMBL162880 | — | — | 1 | 9.15 |
| CHEMBL164484 | — | — | 1 | 8.92 |
| CHEMBL140418 | — | — | 1 | 8.89 |
| CHEMBL140390 | — | — | 1 | 8.70 |
| CHEMBL82301 | VICRIVIROC | 3.0 | 1 | 8.68 |
| CHEMBL335120 | — | — | 1 | 8.68 |
| CHEMBL351625 | — | — | 1 | 8.66 |
| CHEMBL140552 | — | — | 1 | 8.49 |
| CHEMBL140912 | — | — | 1 | 8.48 |
| CHEMBL161587 | — | — | 1 | 8.33 |
| CHEMBL343520 | — | — | 1 | 8.28 |
| CHEMBL141683 | — | — | 1 | 8.24 |
| CHEMBL341758 | — | — | 1 | 8.09 |
| CHEMBL161664 | — | — | 1 | 8.06 |
| CHEMBL344435 | — | — | 1 | 7.96 |
| CHEMBL141201 | — | — | 1 | 7.85 |
| CHEMBL162946 | — | — | 1 | 7.64 |
| CHEMBL139246 | — | — | 1 | 7.60 |
| CHEMBL139701 | — | — | 1 | 7.37 |
| CHEMBL140201 | — | — | 1 | 7.22 |
| CHEMBL342706 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL349008 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL350563 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL162880 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL164484 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL140418 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL140390 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL82301 | VICRIVIROC | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL335120 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL351625 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL140552 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL140912 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL161587 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL343520 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL141683 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL341758 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL161664 | — | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL344435 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL141201 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL162946 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL139246 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL139701 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL140201 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL342706 | — | Ki | = | 315.0 | nM | 6.50 |