Assay Detail
Binding
CHEMBL650154
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Binding affinity towards Angiotensin receptor from rabbit aorta
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Potent, orally active imidazo[4,5-b]pyridine-based angiotensin II receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.82 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2369937 | — | — | 1 | 9.70 |
| CHEMBL315104 | — | — | 1 | 9.52 |
| CHEMBL7550 | L-158809 | — | 1 | 9.52 |
| CHEMBL98907 | — | — | 1 | 9.30 |
| CHEMBL296725 | — | — | 1 | 9.00 |
| CHEMBL99991 | — | — | 1 | 8.70 |
| CHEMBL317360 | — | — | 1 | 8.22 |
| CHEMBL99751 | — | — | 1 | 8.10 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2369937 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL315104 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL7550 | L-158809 | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL98907 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL296725 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL99991 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL317360 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL99751 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL191 | LOSARTAN | IC50 | = | 50.0 | nM | 7.30 |