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Assay Detail

CHEMBL650164

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Binding
Binding affinity against Angiotensin II receptor, from rat adrenal gland
ChEMBL ↗
102
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Tissue Adrenal gland
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Angiotensin II receptor (CHEMBL2094112) ↗
Type PROTEIN FAMILY
Organism Rattus norvegicus

Publication

Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype.
Blankley CJ, Hodges JC, Klutchko SR, Himmelsbach RJ, Chucholowski A, Connolly CJ, Neergaard SJ, Van Nieuwenhze MS, Sebastian A, Quin J.
J Med Chem (1991) 34 : 3248 -3260
PubMed 1956044 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 102 6.15 9.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL404594 — — 1 9.46
CHEMBL408403 ANGIOTENSIN II 4.0 1 8.89
CHEMBL312754 — — 1 8.80
CHEMBL321820 — — 1 7.47
CHEMBL109832 — — 1 7.36
CHEMBL110804 — — 1 7.30
CHEMBL111287 — — 1 7.29
CHEMBL326663 — — 1 7.25
CHEMBL292277 — — 1 7.18
CHEMBL110531 — — 1 7.17
CHEMBL294558 — — 1 7.16
CHEMBL114126 — — 1 7.15
CHEMBL114347 — — 1 7.07
CHEMBL109678 — — 1 7.07
CHEMBL321664 — — 1 7.05
CHEMBL321667 — — 1 7.01
CHEMBL2112328 — — 1 7.01
CHEMBL109562 — — 1 6.96
CHEMBL321221 — — 1 6.96
CHEMBL111046 — — 1 6.92
CHEMBL111977 — — 1 6.92
CHEMBL109921 — — 1 6.89
CHEMBL322259 — — 1 6.85
CHEMBL326246 — — 1 6.85
CHEMBL111253 — — 1 6.82
CHEMBL112874 — — 1 6.82
CHEMBL112970 — — 1 6.72
CHEMBL326042 — — 1 6.70
CHEMBL111382 — — 1 6.62
CHEMBL109446 — — 1 6.62

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL404594 — IC50 = 0.35 nM 9.46
CHEMBL408403 ANGIOTENSIN II IC50 = 1.3 nM 8.89
CHEMBL312754 — IC50 = 1.6 nM 8.80
CHEMBL321820 — IC50 = 34.0 nM 7.47
CHEMBL109832 — IC50 = 44.0 nM 7.36
CHEMBL110804 — IC50 = 50.0 nM 7.30
CHEMBL111287 — IC50 = 51.0 nM 7.29
CHEMBL326663 — IC50 = 56.0 nM 7.25
CHEMBL292277 — IC50 = 66.0 nM 7.18
CHEMBL110531 — IC50 = 67.0 nM 7.17
CHEMBL294558 — IC50 = 70.0 nM 7.16
CHEMBL114126 — IC50 = 71.0 nM 7.15
CHEMBL114347 — IC50 = 85.0 nM 7.07
CHEMBL109678 — IC50 = 85.0 nM 7.07
CHEMBL321664 — IC50 = 89.0 nM 7.05
CHEMBL2112328 — IC50 = 97.0 nM 7.01
CHEMBL321667 — IC50 = 98.0 nM 7.01
CHEMBL321221 — IC50 = 110.0 nM 6.96
CHEMBL109562 — IC50 = 110.0 nM 6.96
CHEMBL111046 — IC50 = 120.0 nM 6.92
CHEMBL111977 — IC50 = 120.0 nM 6.92
CHEMBL109921 — IC50 = 130.0 nM 6.89
CHEMBL326246 — IC50 = 140.0 nM 6.85
CHEMBL322259 — IC50 = 140.0 nM 6.85
CHEMBL112874 — IC50 = 150.0 nM 6.82
CHEMBL111253 — IC50 = 150.0 nM 6.82
CHEMBL112970 — IC50 = 190.0 nM 6.72
CHEMBL326042 — IC50 = 200.0 nM 6.70
CHEMBL109446 — IC50 = 240.0 nM 6.62
CHEMBL111382 — IC50 = 240.0 nM 6.62
CHEMBL111478 — IC50 = 260.0 nM 6.58
CHEMBL419210 — IC50 = 270.0 nM 6.57
CHEMBL110471 — IC50 = 290.0 nM 6.54
CHEMBL432964 — IC50 = 290.0 nM 6.54
CHEMBL111782 — IC50 = 290.0 nM 6.54
CHEMBL109979 — IC50 = 300.0 nM 6.52
CHEMBL2112497 — IC50 = 340.0 nM 6.47
CHEMBL111519 — IC50 = 350.0 nM 6.46
CHEMBL325936 — IC50 = 350.0 nM 6.46
CHEMBL320336 — IC50 = 370.0 nM 6.43
CHEMBL111330 — IC50 = 440.0 nM 6.36
CHEMBL323598 — IC50 = 450.0 nM 6.35
CHEMBL321000 — IC50 = 460.0 nM 6.34
CHEMBL325185 — IC50 = 510.0 nM 6.29
CHEMBL109884 — IC50 = 530.0 nM 6.28
CHEMBL109933 — IC50 = 520.0 nM 6.28
CHEMBL110532 — IC50 = 560.0 nM 6.25
CHEMBL111564 — IC50 = 610.0 nM 6.21
CHEMBL113300 — IC50 = 610.0 nM 6.21
CHEMBL110081 — IC50 = 650.0 nM 6.19