Assay Detail
Binding
CHEMBL650165
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Binding affinity for rat brain Angiotensin II receptor
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.71 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL404594 | — | — | 1 | 10.00 |
| CHEMBL408403 | ANGIOTENSIN II | 4.0 | 1 | 8.40 |
| CHEMBL312754 | — | — | 1 | 8.29 |
| CHEMBL320336 | — | — | 1 | 6.89 |
| CHEMBL109921 | — | — | 1 | 6.77 |
| CHEMBL321820 | — | — | 1 | 6.68 |
| CHEMBL432794 | — | — | 1 | 6.40 |
| CHEMBL112970 | — | — | 1 | 6.10 |
| CHEMBL112874 | — | — | 1 | 5.80 |
| CHEMBL111330 | — | — | 1 | 5.42 |
| CHEMBL324414 | — | — | 1 | 5.09 |
| CHEMBL109616 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL404594 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL408403 | ANGIOTENSIN II | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL312754 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL320336 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL109921 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL321820 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL432794 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL112970 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL112874 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL111330 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL324414 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL109616 | — | IC50 | = | 19000.0 | nM | 4.72 |