Assay Detail
Binding
CHEMBL650237
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Displacement of [3H]idazoxan from alpha-2 adrenergic receptor from rat brain cerebral cortex.
9
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Alpha-adrenoreceptor reagents. 4. Resolution of some potent selective prejunctional alpha 2-adrenoreceptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.71 | 9.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10332 | — | — | 3 | 9.44 |
| CHEMBL61325 | — | — | 3 | 8.62 |
| CHEMBL61234 | — | — | 3 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10332 | — | Ki | = | 0.36 | nM | 9.44 |
| CHEMBL10332 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL61325 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL61325 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL61234 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL61234 | — | Ki | = | 16.3 | nM | 7.79 |
| CHEMBL10332 | — | Ki | = | 256.0 | nM | 6.59 |
| CHEMBL61325 | — | Ki | = | 487.0 | nM | 6.31 |
| CHEMBL61234 | — | Ki | = | 8734.0 | nM | 5.06 |