Assay Detail
Functional
CHEMBL650243
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for its inhibitory activity against human beta-2 adrenergic receptor (AR)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Tetrahydroisoquinoline derivatives containing a benzenesulfonamide moiety as potent, selective human beta3 adrenergic receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.51 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL174984 | TRETOQUINOL | 2.0 | 1 | 8.46 |
| CHEMBL75604 | — | — | 1 | 6.47 |
| CHEMBL312074 | — | — | 1 | 6.24 |
| CHEMBL421871 | — | — | 1 | 5.82 |
| CHEMBL308868 | — | — | 1 | 5.57 |
| CHEMBL74860 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL174984 | TRETOQUINOL | EC50 | = | 3.5 | nM | 8.46 |
| CHEMBL75604 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL312074 | — | EC50 | = | 580.0 | nM | 6.24 |
| CHEMBL421871 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL308868 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL74860 | — | EC50 | > | 1000.0 | nM | - |