Assay Detail
Binding
CHEMBL650308
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Compound was tested for inhibition against Angiotensin II receptor, type 1
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Angiotensin II AT1 receptor antagonists. Clinical implications of active metabolites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.21 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL72838 | ENOLTASOSARTAN | — | 1 | 9.77 |
| CHEMBL74767 | — | — | 1 | 9.33 |
| CHEMBL72053 | — | — | 1 | 7.96 |
| CHEMBL432162 | TASOSARTAN | 2.0 | 1 | 7.50 |
| CHEMBL307191 | — | — | 1 | 7.36 |
| CHEMBL74347 | — | — | 1 | 7.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL72838 | ENOLTASOSARTAN | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL74767 | — | IC50 | = | 0.47 | nM | 9.33 |
| CHEMBL72053 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL432162 | TASOSARTAN | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL307191 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL74347 | — | IC50 | = | 44.0 | nM | 7.36 |