Compound Detail

CHEMBL72838

ENOLTASOSARTAN

Enter ChEMBL ID:

Free Research Context This compound will appear in recent viewed items on the research home for this browser.

Cc1nc(C)c2c(O)cc(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2n1

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL72838
Name	ENOLTASOSARTAN
Phase	Preclinical
Structure Type	MOL
InChI Key	YROKAAIPBSCMJN-UHFFFAOYSA-N

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

425.4

MW (Da)

3.01

ALogP

HBA

HBD

122.5

PSA (Å²)

0.45

QED

Ro5 Violations

Rot. Bonds

First in Class Prodrug

IC50 2 meas. best 9.77

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Angiotensin II receptor (AT-1) type-1 CHEMBL2094250	IC50	9.77	9.77	0.2	1
Type-1 angiotensin II receptor CHEMBL227	IC50	9.77	9.77	0.2	1

Parameter	Value	Units	Species
T1/2	40.0	hr	Homo sapiens

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Type-1 angiotensin II receptor	IC50	=	0.17	nM	9.77	Compound was tested for inhibition against Angiotensin II receptor, type 1	12773029
Angiotensin II receptor (AT-1) type-1	IC50	=	0.17	nM	9.77	Compound was evaluated for the in vitro inhibition of specific binding of [125I]...	9784100

PubMed	DOI	Target Context	# Activities
9784100	10.1021/jm970690q	Rattus norvegicus	4
15974591	10.1021/jm049024x	Type-1 angiotensin II receptor	2
12773029	10.1021/jm0204237	Type-1 angiotensin II receptor	1
12773029	10.1021/jm0204237	ADMET	1
9784100	10.1021/jm970690q	Angiotensin II receptor (AT-1) type-1	1
15974591	10.1021/jm049024x	ADMET	1

Data from ChEMBL 36 via Core Engine