Assay Detail
Binding
CHEMBL647794
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for the in vitro inhibition of specific binding of [125I]-A II to Angiotensin II receptor, type 1 from rat adrenal membranes.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Angiotensin II receptor (AT-1) type-1 (CHEMBL2094250) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Metabolites of the angiotensin II antagonist tasosartan: the importance of a second acidic group.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.98 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL72838 | ENOLTASOSARTAN | — | 1 | 9.77 |
| CHEMBL135574 | — | — | 1 | 9.39 |
| CHEMBL432162 | TASOSARTAN | 2.0 | 1 | 8.92 |
| CHEMBL337067 | — | — | 1 | 8.64 |
| CHEMBL135309 | — | — | 1 | 8.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL72838 | ENOLTASOSARTAN | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL135574 | — | IC50 | = | 0.41 | nM | 9.39 |
| CHEMBL432162 | TASOSARTAN | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL337067 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL135309 | — | IC50 | = | 6.5 | nM | 8.19 |