Assay Detail
Binding
CHEMBL650472
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Inhibitory activity against serine Beta-lactamase derived from Staphylococcus aureus
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
The synthesis and evaluation of 6-alkylidene-2'beta-substituted penam sulfones as beta-lactamase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.98 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL294608 | — | — | 1 | 9.00 |
| CHEMBL303053 | — | — | 1 | 7.58 |
| CHEMBL294203 | — | — | 1 | 7.21 |
| CHEMBL305361 | — | — | 1 | 6.43 |
| CHEMBL292093 | — | — | 1 | 6.27 |
| CHEMBL61760 | — | — | 1 | 6.23 |
| CHEMBL292506 | — | — | 1 | 6.19 |
| CHEMBL61762 | — | — | 1 | 6.15 |
| CHEMBL60491 | — | — | 1 | 5.35 |
| CHEMBL60220 | — | — | 1 | 5.17 |
| CHEMBL304709 | — | — | 1 | 5.07 |
| CHEMBL64056 | — | — | 1 | 5.02 |
| CHEMBL59053 | — | — | 1 | 4.88 |
| CHEMBL292147 | — | — | 1 | 4.86 |
| CHEMBL1439 | TAZOBACTAM SODIUM | 4.0 | 1 | 4.29 |
| CHEMBL59227 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL294608 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL303053 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL294203 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL305361 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL292093 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL61760 | — | IC50 | = | 592.0 | nM | 6.23 |
| CHEMBL292506 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL61762 | — | IC50 | = | 708.0 | nM | 6.15 |
| CHEMBL60491 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL60220 | — | IC50 | = | 6760.0 | nM | 5.17 |
| CHEMBL304709 | — | IC50 | = | 8480.0 | nM | 5.07 |
| CHEMBL64056 | — | IC50 | = | 9510.0 | nM | 5.02 |
| CHEMBL59053 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL292147 | — | IC50 | = | 13910.0 | nM | 4.86 |
| CHEMBL1439 | TAZOBACTAM SODIUM | IC50 | = | 51900.0 | nM | 4.29 |
| CHEMBL59227 | — | IC50 | = | 527000.0 | nM | - |