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Assay Detail

CHEMBL650504

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Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

C-C chemokine receptor type 3 (CHEMBL3473)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design and synthesis of novel CCR3 antagonists.
Gong L, Hogg JH, Collier J, Wilhelm RS, Soderberg C.
Bioorg Med Chem Lett (2003) 13 : 3597 -3600
PubMed 14505678 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 6.92 9.24

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL331897 1 9.24
CHEMBL20921 1 8.64
CHEMBL33227 1 8.30
CHEMBL431670 1 8.09
CHEMBL121905 1 7.96
CHEMBL121637 1 7.92
CHEMBL436363 1 7.19
CHEMBL123943 1 6.30
CHEMBL420709 1 6.30
CHEMBL331702 1 5.77
CHEMBL123308 1 5.75
CHEMBL331672 1 5.28
CHEMBL120957 1 5.11
CHEMBL333040 1 5.07
CHEMBL121588 1 -
CHEMBL121743 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL331897 IC50 = 0.58 nM 9.24
CHEMBL20921 IC50 = 2.3 nM 8.64
CHEMBL33227 IC50 = 5.0 nM 8.30
CHEMBL431670 IC50 = 8.2 nM 8.09
CHEMBL121905 IC50 = 11.0 nM 7.96
CHEMBL121637 IC50 = 12.0 nM 7.92
CHEMBL436363 IC50 = 65.0 nM 7.19
CHEMBL123943 IC50 = 500.0 nM 6.30
CHEMBL420709 IC50 = 500.0 nM 6.30
CHEMBL331702 IC50 = 1700.0 nM 5.77
CHEMBL123308 IC50 = 1800.0 nM 5.75
CHEMBL331672 IC50 = 5300.0 nM 5.28
CHEMBL120957 IC50 = 7800.0 nM 5.11
CHEMBL333040 IC50 = 8500.0 nM 5.07
CHEMBL121588 IC50 > 200000.0 nM -
CHEMBL121743 IC50 > 200000.0 nM -