Assay Detail
Functional
CHEMBL650563
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C6 glioma 3-day proliferation followed by soft agar growth without treatment
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | C6 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and tyrosine kinase inhibitory activity of a series of 2-amino-8H-pyrido[2,3-d]pyrimidines: identification of potent, selective platelet-derived growth factor receptor tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.82 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL134851 | — | — | 1 | 6.82 |
| CHEMBL49120 | PD-0166285 | 1.0 | 1 | 5.75 |
| CHEMBL136106 | — | — | 1 | 4.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL134851 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL49120 | PD-0166285 | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL136106 | — | IC50 | = | 13200.0 | nM | 4.88 |