Assay Detail
Functional
CHEMBL650577
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C6 cell growth in soft agar with continuous treatment
6
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | C6 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
2-Substituted aminopyrido[2,3-d]pyrimidin-7(8H)-ones. structure-activity relationships against selected tyrosine kinases and in vitro and in vivo anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.58 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112914 | — | — | 1 | 6.92 |
| CHEMBL297523 | — | — | 2 | 6.92 |
| CHEMBL49120 | PD-0166285 | 1.0 | 1 | 6.92 |
| CHEMBL104779 | — | — | 1 | 6.40 |
| CHEMBL301612 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112914 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL297523 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL49120 | PD-0166285 | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL104779 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL297523 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL301612 | — | IC50 | = | 1100.0 | nM | 5.96 |