Assay Detail
Functional
CHEMBL650579
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDGF-induced autophosphorylation of PDGF-R in C6 cells
6
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | C6 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Target
Platelet-derived growth factor receptor (PDGFr) (CHEMBL2111344) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
2-Substituted aminopyrido[2,3-d]pyrimidin-7(8H)-ones. structure-activity relationships against selected tyrosine kinases and in vitro and in vivo anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.85 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112914 | — | — | 1 | 9.00 |
| CHEMBL297523 | — | — | 2 | 9.00 |
| CHEMBL49120 | PD-0166285 | 1.0 | 1 | 8.30 |
| CHEMBL301612 | — | — | 1 | 7.42 |
| CHEMBL104779 | — | — | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112914 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL297523 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL49120 | PD-0166285 | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL301612 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL297523 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL104779 | — | IC50 | = | 680.0 | nM | 6.17 |