Assay Detail

CHEMBL650608

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Functional

Effective dose that inhibits cellular growth of CEM cells infected with HIV-1 IIIB strain

ChEMBL ↗

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Target

CCRF-CEM (CHEMBL382) ↗

Open DB target context

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CCRF-CEM (CHEMBL382) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target CCRF-CEM

CHEMBL382

Anchored from Assay target.

Protein identity CCRF-CEM

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	CCRF-CEM
Confidence	1 — Organism
Curated By	Intermediate

Target

CCRF-CEM (CHEMBL382) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Beneficial replacement of the P1 phenylalanine side chain in HIV-1 protease inhibitors of the difluorostatone type

Schirlin D, Van Dorsselaer V, Tarnus C, Taylor D, Tyms A, Baltzer S, Weber F, Remy J, Brennan T, Farr R, Janowick D
Bioorg Med Chem Lett (1994) 4 : 241 -246
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	6.14	6.14

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL15705	—	—	1	6.14

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL15705	—	EC50	=	720.0	nM	6.14