Assay Detail
Functional
CHEMBL650617
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Tested for in vitro drug concentration which produces 50% survival of HIV-1 infected CEM cells relative to uninfected untreated controls
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antiviral (HIV-1, HBV) activities of 5-halo-6-methoxy(or azido)-5,6-dihydro-3'-fluoro-3'-deoxythymidine diastereomers. Potential prodrugs to 3'-fluoro-3'-deoxythymidine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.17 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL105318 | ALOVUDINE | 2.0 | 1 | 9.00 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.52 |
| CHEMBL116767 | — | — | 1 | 8.49 |
| CHEMBL121850 | — | — | 1 | 8.43 |
| CHEMBL118427 | — | — | 1 | 8.28 |
| CHEMBL116319 | — | — | 1 | 7.84 |
| CHEMBL119051 | — | — | 1 | 5.26 |
| CHEMBL334183 | — | — | 1 | 4.42 |
| CHEMBL119448 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL105318 | ALOVUDINE | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL116767 | — | EC50 | = | 3.25 | nM | 8.49 |
| CHEMBL121850 | — | EC50 | = | 3.75 | nM | 8.43 |
| CHEMBL118427 | — | EC50 | = | 5.25 | nM | 8.28 |
| CHEMBL116319 | — | EC50 | = | 14.5 | nM | 7.84 |
| CHEMBL119051 | — | EC50 | = | 5550.0 | nM | 5.26 |
| CHEMBL334183 | — | EC50 | = | 37900.0 | nM | 4.42 |
| CHEMBL119448 | — | EC50 | = | 50000.0 | nM | 4.30 |