Assay Detail
Functional
CHEMBL650623
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was evaluated for prevention of the cytopathic effect of HIV-1 for cytopathicity of HIV-1RF in CEM-SS cells.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of certain alkenyldiarylmethanes as anti-HIV-1 agents which act as non-nucleoside reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.02 | 5.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109573 | — | — | 1 | 5.15 |
| CHEMBL111375 | — | — | 1 | 5.10 |
| CHEMBL110359 | — | — | 1 | 4.80 |
| CHEMBL112780 | — | — | 1 | - |
| CHEMBL324660 | — | — | 1 | - |
| CHEMBL446887 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109573 | — | EC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL111375 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL110359 | — | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL112780 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL324660 | — | EC50 | > | 91500.0 | nM | - |
| CHEMBL446887 | — | EC50 | > | 28000.0 | nM | - |