Assay Detail
Binding
CHEMBL650682
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]Ro-151788 binding to GABA-A central benzodiazepine receptor of bovine brain membranes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Subcellular | Brain membranes |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL2094107) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Bos taurus |
Publication
Synthesis and benzodiazepine receptor affinity of pyrazolo[1,5-a]pyrimidine derivatives. 3. New 6-(3-thienyl) series as alpha 1 selective ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.43 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL322697 | — | — | 1 | 7.80 |
| CHEMBL107228 | — | — | 1 | 7.58 |
| CHEMBL107447 | — | — | 1 | 7.38 |
| CHEMBL320137 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL322697 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL107228 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL107447 | — | Ki | = | 42.2 | nM | 7.38 |
| CHEMBL320137 | — | Ki | = | 111.0 | nM | 6.96 |