Assay Detail
Binding
CHEMBL650684
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Inhibitory activity against class A Beta-lactamase TEM isolated from Enterobacter coli
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Enterobacter cloacae |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
The synthesis and SAR of rhodanines as novel class C beta-lactamase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 4.80 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL404 | TAZOBACTAM | 4.0 | 1 | 7.22 |
| CHEMBL305404 | — | — | 1 | 5.06 |
| CHEMBL69368 | — | — | 1 | 4.50 |
| CHEMBL69612 | — | — | 1 | 4.00 |
| CHEMBL68217 | — | — | 1 | 4.00 |
| CHEMBL68939 | — | — | 1 | 4.00 |
| CHEMBL68042 | — | — | 1 | - |
| CHEMBL303602 | — | — | 1 | - |
| CHEMBL307557 | — | — | 1 | - |
| CHEMBL66070 | — | — | 1 | - |
| CHEMBL302252 | — | — | 1 | - |
| CHEMBL306881 | — | — | 1 | - |
| CHEMBL431550 | — | — | 1 | - |
| CHEMBL67876 | — | — | 1 | - |
| CHEMBL66064 | — | — | 1 | - |
| CHEMBL308010 | — | — | 1 | - |
| CHEMBL305763 | — | — | 1 | - |
| CHEMBL68578 | — | — | 1 | - |
| CHEMBL69428 | — | — | 1 | - |
| CHEMBL303038 | — | — | 1 | - |
| CHEMBL69676 | — | — | 1 | - |
| CHEMBL304529 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL404 | TAZOBACTAM | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL305404 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL69368 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL69612 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL68217 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL68939 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL68042 | — | IC50 | > | 700000.0 | nM | - |
| CHEMBL303602 | — | IC50 | = | 138000.0 | nM | - |
| CHEMBL307557 | — | IC50 | = | 432000.0 | nM | - |
| CHEMBL66070 | — | IC50 | > | 700000.0 | nM | - |
| CHEMBL302252 | — | IC50 | > | 700000.0 | nM | - |
| CHEMBL306881 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL431550 | — | IC50 | > | 700000.0 | nM | - |
| CHEMBL67876 | — | IC50 | > | 700000.0 | nM | - |
| CHEMBL66064 | — | IC50 | > | 700000.0 | nM | - |
| CHEMBL308010 | — | IC50 | = | 190000.0 | nM | - |
| CHEMBL305763 | — | IC50 | > | 700000.0 | nM | - |
| CHEMBL68578 | — | IC50 | > | 700000.0 | nM | - |
| CHEMBL69428 | — | IC50 | > | 700000.0 | nM | - |
| CHEMBL303038 | — | IC50 | > | 700000.0 | nM | - |
| CHEMBL69676 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL304529 | — | IC50 | > | 700000.0 | nM | - |