Assay Detail
Binding
CHEMBL650687
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Compound was tested for inhibition of [3H]dihydroalprenolol radioligand binding to Beta-1 adrenergic receptor in dog heart.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Use of (S)-(trifloxymethyl)oxirane in the synthesis of a chiral beta-adrenoceptor antagonist, (R)- and (S)-9-[[3-(tert-butylamino)-2-hydroxypropyl]oximino]fluorene.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.47 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL266195 | ALPRENOLOL | 2.0 | 1 | 8.31 |
| CHEMBL305153 | — | — | 1 | 7.53 |
| CHEMBL368457 | — | — | 1 | 7.42 |
| CHEMBL1788270 | — | — | 1 | 7.36 |
| CHEMBL26917 | — | — | 1 | 6.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL266195 | ALPRENOLOL | IC50 | = | 4.88 | nM | 8.31 |
| CHEMBL305153 | — | IC50 | = | 29.4 | nM | 7.53 |
| CHEMBL368457 | — | IC50 | = | 37.9 | nM | 7.42 |
| CHEMBL1788270 | — | IC50 | = | 43.3 | nM | 7.36 |
| CHEMBL26917 | — | IC50 | = | 186.0 | nM | 6.73 |