Assay Detail
Functional
CHEMBL650719
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In vitro inhibition of insulin release from murine beta-TC6 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Beta-TC6 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Phenylcyanoguanidines as inhibitors of glucose-induced insulin secretion from beta cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.36 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50179 | — | — | 1 | 6.16 |
| CHEMBL48923 | — | — | 1 | 5.70 |
| CHEMBL298121 | — | — | 1 | 5.64 |
| CHEMBL48433 | — | — | 1 | 5.43 |
| CHEMBL298075 | — | — | 1 | 5.41 |
| CHEMBL48666 | — | — | 1 | 5.34 |
| CHEMBL301508 | — | — | 1 | 5.30 |
| CHEMBL181 | DIAZOXIDE | 4.0 | 1 | 4.65 |
| CHEMBL48197 | — | — | 1 | 4.57 |
| CHEMBL50968 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50179 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL48923 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL298121 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL48433 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL298075 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL48666 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL301508 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL181 | DIAZOXIDE | IC50 | = | 22400.0 | nM | 4.65 |
| CHEMBL48197 | — | IC50 | = | 26700.0 | nM | 4.57 |
| CHEMBL50968 | — | IC50 | > | 100000.0 | nM | - |