Assay Detail
Binding
CHEMBL650800
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Inhibition of [3H]PK11195 binding to mitochondrial rat testis Peripheral type benzodiazepine receptor (PBR)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis of new molecular probes for investigation of steroid biosynthesis induced by selective interaction with peripheral type benzodiazepine receptors (PBR).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.66 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135514 | — | — | 1 | 9.70 |
| CHEMBL445583 | — | — | 1 | 9.51 |
| CHEMBL336774 | — | — | 1 | 9.02 |
| CHEMBL132915 | — | — | 1 | 8.22 |
| CHEMBL135327 | — | — | 1 | 7.96 |
| CHEMBL135807 | — | — | 1 | 7.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135514 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL445583 | — | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL336774 | — | Ki | = | 0.96 | nM | 9.02 |
| CHEMBL132915 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL135327 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL135807 | — | Ki | = | 29.0 | nM | 7.54 |