Assay Detail
Binding
CHEMBL650802
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Binding affinity constant for peripheral (mitochondrial) Benzodiazepine receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A concerted study using binding measurements, X-ray structural data, and molecular modeling on the stereochemical features responsible for the affinity of 6-arylpyrrolo[2,1-d][1,5]benzothiazepines toward mitochondrial benzodiazepine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.65 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL288551 | — | — | 1 | 8.05 |
| CHEMBL116087 | — | — | 1 | 7.52 |
| CHEMBL286909 | — | — | 1 | 7.02 |
| CHEMBL358133 | — | — | 1 | 5.50 |
| CHEMBL142639 | — | — | 1 | 5.16 |
| CHEMBL317219 | — | — | 1 | - |
| CHEMBL284371 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL288551 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL116087 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL286909 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL358133 | — | Ki | = | 3150.0 | nM | 5.50 |
| CHEMBL142639 | — | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL317219 | — | Ki | > | 10.0 | nM | - |
| CHEMBL284371 | — | Ki | > | 10.0 | nM | - |