Assay Detail
Binding
CHEMBL650819
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of [3H]- flunitrazepam binding to GABA-A benzodiazepine receptor of bovine cortical membranes
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL2094107) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Bos taurus |
Publication
Synthesis, structure-activity relationships, and molecular modeling studies of N-(indol-3-ylglyoxylyl)benzylamine derivatives acting at the benzodiazepine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 6.85 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308760 | — | — | 1 | 7.96 |
| CHEMBL149545 | — | — | 1 | 7.89 |
| CHEMBL146284 | — | — | 1 | 7.57 |
| CHEMBL75212 | — | — | 1 | 7.52 |
| CHEMBL357844 | — | — | 1 | 7.42 |
| CHEMBL148858 | — | — | 1 | 7.32 |
| CHEMBL127135 | — | — | 1 | 7.28 |
| CHEMBL75306 | — | — | 1 | 7.28 |
| CHEMBL73288 | — | — | 1 | 7.17 |
| CHEMBL306370 | — | — | 1 | 7.03 |
| CHEMBL74280 | — | — | 1 | 6.97 |
| CHEMBL75307 | — | — | 1 | 6.93 |
| CHEMBL75289 | — | — | 1 | 6.92 |
| CHEMBL145980 | — | — | 1 | 6.85 |
| CHEMBL146145 | — | — | 1 | 6.82 |
| CHEMBL358147 | — | — | 1 | 6.80 |
| CHEMBL146434 | — | — | 1 | 6.79 |
| CHEMBL306310 | — | — | 1 | 6.79 |
| CHEMBL278470 | — | — | 1 | 6.75 |
| CHEMBL356272 | — | — | 1 | 6.54 |
| CHEMBL358763 | — | — | 1 | 6.46 |
| CHEMBL147868 | — | — | 1 | 6.37 |
| CHEMBL74589 | — | — | 1 | 6.31 |
| CHEMBL145850 | — | — | 1 | 6.18 |
| CHEMBL344308 | — | — | 1 | 6.00 |
| CHEMBL344344 | — | — | 1 | 5.58 |
| CHEMBL423758 | — | — | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308760 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL149545 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL146284 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL75212 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL357844 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL148858 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL127135 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL75306 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL73288 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL306370 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL74280 | — | Ki | = | 107.0 | nM | 6.97 |
| CHEMBL75307 | — | Ki | = | 117.0 | nM | 6.93 |
| CHEMBL75289 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL145980 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL146145 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL358147 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL146434 | — | Ki | = | 162.0 | nM | 6.79 |
| CHEMBL306310 | — | Ki | = | 163.0 | nM | 6.79 |
| CHEMBL278470 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL356272 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL358763 | — | Ki | = | 349.0 | nM | 6.46 |
| CHEMBL147868 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL74589 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL145850 | — | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL344308 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL344344 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL423758 | — | Ki | = | 2700.0 | nM | 5.57 |