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Assay Detail

CHEMBL650822

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro inhibition of [3H]-Ro- 15-1788 binding to GABA-A Benzodiazepine receptor of bovine brain membranes
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Subcellular Brain membranes
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

GABA-A receptor; anion channel (CHEMBL2094107)
Type PROTEIN COMPLEX GROUP
Organism Bos taurus

Publication

N'-Phenylindol-3-ylglyoxylohydrazide derivatives: synthesis, structure-activity relationships, molecular modeling studies, and pharmacological action on brain benzodiazepine receptors.
Da Settimo A, Primofiore G, Da Settimo F, Marini AM, Novellino E, Greco G, Gesi M, Martini C, Giannaccini G, Lucacchini A.
J Med Chem (1998) 41 : 3821 -3830
PubMed 9748357 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 2 9.06 9.07

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL452 CLONAZEPAM 4.0 1 9.07
CHEMBL407 FLUMAZENIL 4.0 1 9.05

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL452 CLONAZEPAM Ki = 0.85 nM 9.07
CHEMBL407 FLUMAZENIL Ki = 0.9 nM 9.05