Assay Detail

CHEMBL650836

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Binding

Inhibition of GABA-A benzodiazepine receptor

ChEMBL ↗

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Target

GABA-A receptor; anion channel (CHEMBL1907607) ↗

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GABA-A receptor; anion channel (CHEMBL1907607) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target GABA-A receptor; anion channel

CHEMBL1907607

Anchored from Assay target.

Protein identity GABA-A receptor; anion channel

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Rattus norvegicus
Confidence	5 — Multiple protein complex / RNA
Curated By	Autocuration

Target

GABA-A receptor; anion channel (CHEMBL1907607) ↗

Type	PROTEIN COMPLEX GROUP
Organism	Rattus norvegicus

Publication

Substituted 3-(2-benzoxazyl)-benzimidazol-2-(1H)-ones: a new class of GABA(A) brain receptor ligands.

DeSimone RW, Blum CA.
Bioorg Med Chem Lett (2000) 10 : 2723 -2726
PubMed 11133077 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	9.40	9.40

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL19732	CGS-8216	—	1	9.40

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL19732	CGS-8216	IC50	=	0.4	nM	9.40