Assay Detail
Binding
CHEMBL650854
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for human Beta-2 adrenergic receptor expressed in CHO cells by radioligand competition binding assays using [125I]iodocyanopindolol (ICYP)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Iodinated analogs of trimetoquinol as highly potent and selective beta 2-adrenoceptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 8.14 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL122757 | — | — | 1 | 9.52 |
| CHEMBL120278 | — | — | 1 | 8.82 |
| CHEMBL123596 | — | — | 1 | 8.81 |
| CHEMBL121704 | — | — | 1 | 8.70 |
| CHEMBL308351 | — | — | 1 | 8.69 |
| CHEMBL122990 | — | — | 1 | 8.19 |
| CHEMBL332964 | — | — | 1 | 8.11 |
| CHEMBL122992 | — | — | 1 | 8.06 |
| CHEMBL121964 | — | — | 1 | 7.93 |
| CHEMBL174984 | TRETOQUINOL | 2.0 | 1 | 7.36 |
| CHEMBL333438 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL122757 | — | Ki | = | 0.302 | nM | 9.52 |
| CHEMBL120278 | — | Ki | = | 1.514 | nM | 8.82 |
| CHEMBL123596 | — | Ki | = | 1.549 | nM | 8.81 |
| CHEMBL121704 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL308351 | — | Ki | = | 2.042 | nM | 8.69 |
| CHEMBL122990 | — | Ki | = | 6.457 | nM | 8.19 |
| CHEMBL332964 | — | Ki | = | 7.762 | nM | 8.11 |
| CHEMBL122992 | — | Ki | = | 8.71 | nM | 8.06 |
| CHEMBL121964 | — | Ki | = | 11.75 | nM | 7.93 |
| CHEMBL174984 | TRETOQUINOL | Ki | = | 43.65 | nM | 7.36 |
| CHEMBL333438 | — | Ki | = | 4365.16 | nM | 5.36 |