Assay Detail
Binding
CHEMBL650869
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]diazepam from rat brain GABA-A benzodiazepine receptor
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL1907607) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Design of nonpeptidal ligands for a peptide receptor: cholecystokinin antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.05 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL452 | CLONAZEPAM | 4.0 | 1 | 8.77 |
| CHEMBL13280 | FLUNITRAZEPAM | 4.0 | 1 | 8.77 |
| CHEMBL12 | DIAZEPAM | 4.0 | 1 | 8.15 |
| CHEMBL1907931 | — | — | 1 | 5.25 |
| CHEMBL283117 | ASPERLICIN | — | 1 | 4.30 |
| CHEMBL1907740 | — | — | 1 | - |
| CHEMBL1907714 | — | — | 1 | - |
| CHEMBL1907741 | — | — | 1 | - |
| CHEMBL1907739 | — | — | 1 | - |
| CHEMBL1907728 | — | — | 1 | - |
| CHEMBL70728 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL452 | CLONAZEPAM | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL13280 | FLUNITRAZEPAM | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL12 | DIAZEPAM | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1907931 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL283117 | ASPERLICIN | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL1907740 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1907714 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1907741 | — | IC50 | > | 180000.0 | nM | - |
| CHEMBL1907739 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1907728 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL70728 | — | IC50 | > | 100000.0 | nM | - |