Assay Detail
Binding
CHEMBL651042
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Binding affinity against Beta-2 adrenergic receptor in guinea pig lung membranes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Lung |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis of halogenated trimetoquinol derivatives and evaluation of their beta-agonist and thromboxane A2 (TXA2) antagonist activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.03 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1788251 | — | — | 1 | 7.35 |
| CHEMBL174984 | TRETOQUINOL | 2.0 | 1 | 7.31 |
| CHEMBL2092996 | — | — | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1788251 | — | Ki | = | 44.67 | nM | 7.35 |
| CHEMBL174984 | TRETOQUINOL | Ki | = | 48.98 | nM | 7.31 |
| CHEMBL2092996 | — | Ki | = | 371.54 | nM | 6.43 |