Assay Detail
Binding
CHEMBL651052
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Displacement of [3H]prazosin from human cloned Alpha-1B adrenergic receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
WB 4101-related compounds. 2. Role of the ethylene chain separating amine and phenoxy units on the affinity for alpha(1)-adrenoreceptor subtypes and 5-HT(1A) receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.98 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25554 | — | — | 1 | 8.00 |
| CHEMBL13647 | BMY-7378 | — | 1 | 7.16 |
| CHEMBL134428 | — | — | 1 | 7.03 |
| CHEMBL135974 | — | — | 1 | 5.74 |
| CHEMBL132378 | — | — | 1 | - |
| CHEMBL56 | 8-OH-DPAT | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25554 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL13647 | BMY-7378 | Ki | = | 69.18 | nM | 7.16 |
| CHEMBL134428 | — | Ki | = | 93.33 | nM | 7.03 |
| CHEMBL135974 | — | Ki | = | 1819.7 | nM | 5.74 |
| CHEMBL132378 | — | Ki | < | 1000.0 | nM | - |
| CHEMBL56 | 8-OH-DPAT | Ki | < | 1000.0 | nM | - |