Assay Detail
Binding
CHEMBL651103
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Inhibitory activity against serine beta-lactamase, PC1 (class A) derived from Staphylococcus aureus
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
The synthesis and evaluation of 6-alkylidene-2'beta-substituted penam sulfones as beta-lactamase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.61 | 6.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL294608 | — | — | 1 | 6.41 |
| CHEMBL294203 | — | — | 1 | 6.18 |
| CHEMBL303053 | — | — | 1 | 6.16 |
| CHEMBL304709 | — | — | 1 | 5.66 |
| CHEMBL1439 | TAZOBACTAM SODIUM | 4.0 | 1 | 5.59 |
| CHEMBL64793 | — | — | 1 | 5.14 |
| CHEMBL61762 | — | — | 1 | 4.12 |
| CHEMBL60220 | — | — | 1 | - |
| CHEMBL59053 | — | — | 1 | - |
| CHEMBL61760 | — | — | 1 | - |
| CHEMBL292147 | — | — | 1 | - |
| CHEMBL292093 | — | — | 1 | - |
| CHEMBL59227 | — | — | 1 | - |
| CHEMBL60491 | — | — | 1 | - |
| CHEMBL305361 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL294608 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL294203 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL303053 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL304709 | — | IC50 | = | 2210.0 | nM | 5.66 |
| CHEMBL1439 | TAZOBACTAM SODIUM | IC50 | = | 2570.0 | nM | 5.59 |
| CHEMBL64793 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL61762 | — | IC50 | = | 76530.0 | nM | 4.12 |
| CHEMBL60220 | — | IC50 | = | 504000.0 | nM | - |
| CHEMBL59053 | — | IC50 | = | 939700.0 | nM | - |
| CHEMBL61760 | — | IC50 | = | 173000.0 | nM | - |
| CHEMBL292147 | — | IC50 | = | 432000.0 | nM | - |
| CHEMBL292093 | — | IC50 | = | 579000.0 | nM | - |
| CHEMBL59227 | — | IC50 | = | 2100000.0 | nM | - |
| CHEMBL60491 | — | IC50 | = | 108000.0 | nM | - |
| CHEMBL305361 | — | IC50 | = | 116000.0 | nM | - |