Assay Detail
Functional
CHEMBL651141
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Agonistic activity against human Beta-3 adrenergic receptor as cAMP accumulation in CHO cells expressing beta3-AR
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel and potent human and rat beta3-adrenergic receptor agonists containing substituted 3-indolylalkylamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 8.95 | 10.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279260 | RAFABEGRON | 2.0 | 1 | 10.80 |
| CHEMBL284782 | — | — | 1 | 10.02 |
| CHEMBL26183 | — | — | 1 | 9.82 |
| CHEMBL26393 | — | — | 1 | 9.44 |
| CHEMBL25133 | — | — | 1 | 9.01 |
| CHEMBL24350 | — | — | 1 | 8.92 |
| CHEMBL286818 | — | — | 1 | 8.19 |
| CHEMBL279931 | — | — | 1 | 7.96 |
| CHEMBL25823 | — | — | 1 | 7.89 |
| CHEMBL282039 | — | — | 1 | 7.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279260 | RAFABEGRON | EC50 | = | 0.016 | nM | 10.80 |
| CHEMBL284782 | — | EC50 | = | 0.095 | nM | 10.02 |
| CHEMBL26183 | — | EC50 | = | 0.15 | nM | 9.82 |
| CHEMBL26393 | — | EC50 | = | 0.36 | nM | 9.44 |
| CHEMBL25133 | — | EC50 | = | 0.97 | nM | 9.01 |
| CHEMBL24350 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL286818 | — | EC50 | = | 6.5 | nM | 8.19 |
| CHEMBL279931 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL25823 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL282039 | — | EC50 | = | 33.0 | nM | 7.48 |