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Compound Detail

CHEMBL279931

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C[C@H](Cc1c[nH]c2ccccc12)NC[C@@H](O)c1cccc(Cl)c1

Basic Information

ChEMBL ID CHEMBL279931
Phase Preclinical
Structure Type MOL
InChI Key AGWBMRMDTWHPJM-BFUOFWGJSA-N
3
Targets
7
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

328.8
MW (Da)
4.08
ALogP
2
HBA
3
HBD
48.0
PSA (Ų)
0.64
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H21ClN2O
MW 328.84
Aromatic Rings 3
Heavy Atoms 23
NP-Likeness -0.61

Activity Summary

EC50 7 meas. best 7.96

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-3 adrenergic receptor
CHEMBL246
EC50 7.96 7.0933 11.0 3
Beta-1 adrenergic receptor
CHEMBL213
EC50 7.33 7.33 47.0 2
Beta-2 adrenergic receptor
CHEMBL210
EC50 6.48 6.48 330.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
12657269 10.1016/s0960-894x(03)00073-8 Beta-3 adrenergic receptor 4
12657269 10.1016/s0960-894x(03)00073-8 Beta-2 adrenergic receptor 2
12657269 10.1016/s0960-894x(03)00073-8 Beta-1 adrenergic receptor 2
21170122 10.1007/s00044-009-9257-x Beta-1 adrenergic receptor 1
21170122 10.1007/s00044-009-9257-x Beta-2 adrenergic receptor 1
21170122 10.1007/s00044-009-9257-x Beta-3 adrenergic receptor 1

Data from ChEMBL 36 via Core Engine