Assay Detail
Functional
CHEMBL651563
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Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel and potent human and rat beta3-adrenergic receptor agonists containing substituted 3-indolylalkylamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.72 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26183 | — | — | 1 | 9.89 |
| CHEMBL26393 | — | — | 1 | 8.72 |
| CHEMBL279260 | RAFABEGRON | 2.0 | 1 | 8.19 |
| CHEMBL25823 | — | — | 1 | 8.03 |
| CHEMBL24350 | — | — | 1 | 7.85 |
| CHEMBL279931 | — | — | 1 | 7.33 |
| CHEMBL286818 | — | — | 1 | 6.89 |
| CHEMBL282039 | — | — | 1 | 6.85 |
| CHEMBL284782 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26183 | — | EC50 | = | 0.13 | nM | 9.89 |
| CHEMBL26393 | — | EC50 | = | 1.9 | nM | 8.72 |
| CHEMBL279260 | RAFABEGRON | EC50 | = | 6.4 | nM | 8.19 |
| CHEMBL25823 | — | EC50 | = | 9.4 | nM | 8.03 |
| CHEMBL24350 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL279931 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL286818 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL282039 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL284782 | — | EC50 | = | 1700.0 | nM | 5.77 |