Assay Detail
Functional
CHEMBL883250
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Agonistic activity against human Beta-2 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel and potent human and rat beta3-adrenergic receptor agonists containing substituted 3-indolylalkylamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.41 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26183 | — | — | 1 | 8.28 |
| CHEMBL279260 | RAFABEGRON | 2.0 | 1 | 7.89 |
| CHEMBL25133 | — | — | 1 | 7.64 |
| CHEMBL26393 | — | — | 1 | 7.60 |
| CHEMBL284782 | — | — | 1 | 6.54 |
| CHEMBL279931 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26183 | — | EC50 | = | 5.2 | nM | 8.28 |
| CHEMBL279260 | RAFABEGRON | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL25133 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL26393 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL284782 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL279931 | — | EC50 | = | 330.0 | nM | 6.48 |